Friday, May 24, 2013

Opiates in the News

Last Friday the Organization of American States released two groundbreaking reports on the future of drug policy in the Americas. Good coverage from CATO and Transform (links below). The Canadian Drug Policy Coalition, headquartered at Simon Fraser University, released a report calling for the legalization of marijuana and decriminalization of "hard" drugs heroin, cocaine and methamphetamine. Meanwhile also in Canada drug users are suing the city of Abbotsford for preventing the implementation of harm reduction services. In Australia, syringe vending machines could offer 24 hour access to harm reduction equipment.
Ibogaine is in the news again. More news on Senator Joseph McCarthy, a lifelong opiate addict, and his source of morphine. Finally I included an interview with two heroin dependent sex workers from Russia. The article is hard to read, the women are regularly raped, beaten, robbed and degraded. The worst offenders are the police.

Here's the links:

A Look at the OAS Report on Drug Policy in the Americas from CATO

Organization of American States launches groundbreaking report exploring alternatives to the war on drugs from the Transform Drug Policy Foundation

A Public Vote Shouldn't Decide Drug Users' Access to Health Care

Imagine if your city government decided to take a public vote to determine whether you and your family members should have access to health care. Based on what the public decides about your mother and her illness, and not what her doctors, your city government says it will pass a bylaw that prevents her and others in her situation from receiving that treatment in their home community. Maybe they decide that your mother is not entitled to receive the insulin she needs to manage her diabetes. Preposterous and unreasonable? Absolutely. But, this is exactly what happens when municipal governments decide to ban harm reduction services based on public opinion and stigma about drugs and the people who use them.

Decriminalize heroin, cocaine and methamphetamines to fight addiction, B.C. report says

“While countries all around the world are adopting forward-thinking, evidence-based drug policies, Canada is taking a step backwards and strengthening punitive policies that have been proven to fail,” states a summary of the 112-page report from the Canadian Drug Policy Coalition, headquartered at Simon Fraser University’s Centre for Applied Research in Mental Health and Addiction.[snip] 
But by far the most controversial recommendation calls for the end to prohibition of not only “soft” drugs like marijuana, but also products like heroin, cocaine and methamphetamines.
The report notes that at least 25 jurisdictions around the world have moved to decriminalize at least some drugs, with Portugal in 2001 and the Czech Republic in 2010 ending prohibition for all drugs. 
“After decriminalization and similar to Portugal, drug use (among Czechs) has not increased significantly but the social harms of drug use have declined,” the report stated.
“In Portugal decriminalization has had the effect of decreasing the numbers of people injecting drugs, decreasing the number of people using drugs problematically, and decreasing trends of drug use among 15 to 24 year olds.”
VICE on HBO: Can an Obscure -- and Illegal -- African Plant Help Cure Heroin and Opiate Addiction?
Ibogaine is a psychoactive alkaloid naturally occurring in the West African shrub iboga. While it is a mild stimulant in small doses, in larger doses it induces a profound psychedelic state. Historically, it has been used in healing ceremonies and initiations by members of the Bwiti religion in various parts of West Africa. People with problematic substance use have found that larger doses of ibogaine can significantly reduce withdrawal from opiates and temporarily eliminate substance-related cravings.
According to the country’s first de-facto drug czar, Harry Anslinger, McCarthy’s addiction was enabled by the federal government. Anslinger, who served as chief of the Federal Bureau of Narcotics from 1930 to 1962, is credited with successfully demonizing “marijuana” as causing addiction and insanity, murder and mayhem. More than any other political figure, Anslinger was responsible for criminalizing opiates and its users. And his word was gospel when it came to the country’s nascent war on drugs. 
In his 1961 memoir, The Murderers, Anslinger wrote about finding out, in the 1950s, that a prominent senator (whom he left unnamed) was addicted to morphine. When confronted by Anslinger, the politician refused to stop, even daring Anslinger to reveal his addiction, saying it would cause irreparable harm to the “Free World.”  Anslinger responded to this gambit by securing the lawmaker a steady supply of dope from a Washington, DC, pharmacy. (Morphine taken by prescription was, then as now, legal.) 
Anslinger’s acquiescence was a testament to just how feared McCarthy was in his heyday. Few dared to speak above a whisper about his evident alcoholism. “[He] went on for some time, guaranteed his morphine because it was underwritten by the Bureau," Anslinger wrote. "On the day he died I thanked God for relieving me of my burden."
“Who’s going to believe us? We’re not people, we’re animals”

The war on drugs has been going on for the last 50 years.  And yet, there is just as much drugs in the world and just as many drug users.  The war on drugs hasn’t made treatment and care any more accessible.  Its only achievement is that it’s profited the ones in power at the expense of other people’s misfortunes, while filling the lives of the sick and impoverished drug users with even more humiliation and suffering. 
 One of the outcomes of the war is that drug users are treated as outcasts who are denied their basic rights.  They have nowhere to turn for help. And those who are supposed to be protecting them–our so-called “law enforcement” officers–rape, abuse and kill them. The most vulnerable, powerless, and disparaged victims of this war are women.

Assorted Links:


Syringe Vending Machines Proposed in Australia

The Importance of Good Samaritan Laws: Jon Bon Jovi recalls his sadness when his daughter suffered a heroin overdose

American Teens Are Being Trapped in Abusive 'Drug Rehab Centres'

Is the INCB Dangerous to Your Health? 5 Ways the UN’s Drug Watchdog Fails on Health and Human Rights

From Twitter:

OpPoppyField ‏@BobD1984
Fed Govt is the drunken step-dad nobody asked for. Willing to beat and imprison you for using "drugs".I have a father. I don't need a daddy.

 The Colbert Report ‏@ColbertReport
"I'm no fan of drugs, they're immoral. Hey, drug mules, swallow that heroin without a condom. Family values."

 The House I Live In ‏@DrugWarMovie
"There's so much Orwelian euphemism in new laws which are being created. Politician are making laws to feed the monster of profiteering" EJ

 jess cochrane ‏@jkcochrane
"There's nothing about my pee that tells you how I parent." - @LynnPaltrow of @NAPW #warofthewomb #criminalizingparents

 Erowid Center ‏@erowid
Thoughts are free and are subject to no rule.”
— Paracelsus (1493–1541)

Follow me on Twitter @opiophilia for regular updates on articles of interest.

Friday, May 17, 2013

Heroin in the United States: Where does it come from, how much does it cost and how pure is it?


I recently read an interesting paper on the US heroin market. Ever wondered where does the heroin in the US come from, how pure it is or how much it costs? This paper answers those questions. I summarize the salient points in this post. The paper with a link to the pdf can be found here:

The Entry of Colombian Heroin into the US Market: The Relationship between Competition, Price, and Purity. Daniel Rosenblum , Jay Unick†, Daniel Ciccarone‡ April 8, 2013 [Link]


Where Does it Come From?
In the US heroin is largely supplied from two source countries, Mexico and Colombia. Colombian heroin made its way onto the US market in the early 1990's, and has since dominated the east coast. The introduction of Colombian heroin also coincided with a significant drop in price.
How Pure is it?

Heroin is usually found as a hydrochloride salt or free base (HCL/B - 82% samples), a grey or white powder sometimes called "china white". Occasionally it comes in other forms such as "black tar", in this paper these samples were labeled salt undetermined (HSU - 16% samples). Purity estimates are for retail amounts from 0.1 to 1.0 grams. Generally the HSU heroin is less pure with the majority of samples below 40% pure. Though more pure on average than HSU heroin, HCL/B heroin has a very evenly distributed purity. Samples range from high to low purity, I guess it depends on where you buy. 

How much does it cost?

Heroin is sold either as individual doses, usually in $10 "bags", or by weight. When sold by weight retail amounts are in fractions of a gram, 1/2 grams, 1/4 grams and 1/10th of a gram (a "point"). Visit a blog devoted to dope bags here. Pictured are several "bags" of heroin, which is an individual dose packaged in wax paper stamped with a logo. The stamp name often comes from popular culture and allows dealers to develop a brand. Also pictured is HCL/B powder, and HSU "black tar" heroin. 
As expected there is some variation in the price of a non-pure gram of heroin. However from the distribution we can see that most heroin costs less than $200 per non-pure gram, and the vast majority below $400. HCL heroin is more expensive, which is consistent with its higher quality. 

Price per pure gram.

The price of heroin has been steadily declining since the 1990's. Nationally the price per pure gram for HCL/ B heroin (the most common type) is about $500. There is significant variation regionally as the final graph demonstrates. It is safe to say that most users are paying about 50 cents per milligram for heavily adulterated diacetylmorphine. 
Heroin Price by Region


Price Inflation Due to Prohibition

The following two tables list the cost of opium necessary to produce a gram of heroin. The price varies, but at most the opium costs $6 and may be as cheap as 11 cents. By the time that gram of opium is converted into heroin, smuggled into the destination country, repackaged and sold in retail units the cost jumps to over $800 (paper from 2003 so may not reflect the price drop discussed above)! For the sake of argument, let us assume the price of opium needed for a gram of heroin is $3. Now let's also say the price doubles at each step in the distribution, so the heroin produced now costs $6 per gram. Transit to consumer countries raises the price to $12 per gram, and finally after repackaging and retail distribution the cost to the user is $24 per gram. As I noted above the national average cost of heroin is $500 per gram. Based on this estimate prohibition raises the price by a factor of nearly 21, in other words heroin is 21 times as expensive as it would be if not illegal. 


The other way we can observe the effect of prohibition on heroin prices is by looking at the cost of legal morphine. Heroin is easily made from morphine, while this step might slightly raise the cost, heroin also weighs more so I doubt this would dramatically increase the cost. Mallinkrodt sells morphine at a per gram cost of $10.61 per gram, in a legal marketplace heroin should sell for a similar amount ($0.01061/milligram). Therefore we can estimate than prohibition inflates the price of heroin by a factor of 50 (ie under legalization heroin would be 50 times cheaper or about $10 per pure gram). 

THE EFFECT OF DRUG PROHIBITION ON DRUG PRICES: EVIDENCE FROM THE MARKETS FOR COCAINE AND HEROIN Jeffrey A. Miron. 2003 [Link]


Worldwide Distribution of Licit Morphine


Tuesday, May 7, 2013

After the War on Drugs, Opioids in a Free Marketplace

    What would a legal market for opioids look like after the end of prohibition? An ideal situation would respect people's rights to use opioids for recreation or self-medication while also seeking to minimize harms. The major risks due to recreational use is mainly an acute overdose, chronic administration also includes a risk of acute overdose as well as dependence (tolerance and withdrawal).


In the case of opioids, there are many factors at play in determining the overall safety of the drugs. The only serious risk with opioids is the acute risk of toxicity. Aside from this, opioids cause no organic tissue damage to the organs or otherwise, even taken over years. The sole mechanism behind acute opioid toxicity is respiratory depression - via a reduction in brain responsiveness/sensitivity to increasing CO2 levels.
Respiratory depression is mediated via the mu-2 receptor subtype, whereas analgesia and euphoria is mediated via the mu-1 receptor type. Therefore, we can conclude that the rate at which tolerance develops (if even at all) may not be consistent between these two distinctly mediated effects.
-Project Narco

    Traditional opiates such as morphine act on both mu receptor subtypes. As the dosage increases to provide additional analgesic or euphorigenic effect there is a corresponding increase in respiratory depression. At a high enough dose breathing stops altogether and the individual may die without administration of an opioid antagonist (naloxone) or artificial respiration. 
A synthetic opioid that has a higher affinity for the mu-1 receptor subtype than the mu-2 subtype would be significantly safer. The synthetic opioid sufentanil, a fentanyl analog, appears to do just that. It has a therapeutic index of approximately 25,000, the highest among the commercially available opioids. Sufentanil is highly lipophilic and easily absorbed through mucosal tissues. For recreational uses it could be formulated similar to "bresh freshener" strips that dissolve under the tongue. A variety of dosages (such light, medium, heavy) could be made available to age appropriate consumers depending on the experience desired. A drug delivery mechanism similar to electronic cigarettes could offer an alternative, fast acting delivery mechanism. 
    Further research could provide a number of synthetic opioids with different pharmacokinetics. Opioids with short half-lives would allow someone to get high during their lunch break and be sober by the time they return to work. The important point is that the large therapeutic index of sufentanil puts it squarely at the top of the safest recreational drugs, in the same ballpark as cannabis and LSD. Cannabis users love to point out that no one has ever died from smoking cannabis, if opioids were as safe a major objection to their recreational use would be removed.
    Opium itself is also a relatively safe drug, certainly no more dangerous than alcohol (and arguably quite a bit less so.) Establishments for smoking opium (opium dens) would be available for those who prefer a "natural" experience. Proprietors would be both trained and equipped to handle an accidental overdose, though there is little evidence that overdoses would be any more common in an opium den than an alcohol bar.

Medication

    Low doses of opioids would be available over the counter much like codeine is some countries. For highly concentrated formulations greater restrictions may be necessary. Ampules for IV use of concentrated and potent opioids such as diamorphine (heroin) or hydromorphone (dilaudid) do have some risk in the hands of ignorant and reckless users. For this reason I suggest two restrictions on distribution. The first is the current prescription system where a qualified medical practitioner could provide some quantity of the medication with detailed instructions on its use. 
    The second restriction would be a licensing system akin to driver's licenses. It is generally conceded that an automobile can be a dangerous machine in the wrong hands. Their use is limited to adults who must also demonstrate a certain level of competency. I propose a similar licensing system for the purchase and use of the more dangerous drugs. To receive a license to purchase and use such drugs, an individual would first have to demonstrate competency. A basic knowledge of pharmacokinetics, safe injection practices, overdosing symptoms and treatment and safe disposal of syringes would be required before a license is issued.
    With the proper license, the individual may then purchase sterile ampules of the opioid of their choice and the knowledge to use it safely. Recreational users would have less choices, but far safer one's. Far fewer people would die from acute overdoses or diseases not specifically caused by opiate use, but a result of our misguided drug policies. 

Wednesday, April 17, 2013

Doctor Arrogance

There are many reasons to end drug prohibition. The usual one's cited are eliminating the black markets, improving the purity and safety of drug dosages, reforming America's unconscionable system of mass incarceration and ending the violence and corruption endemic to producer and transit countries. There are numerous other examples, but there is one reason that is consistently overlooked.

Restoring the Honor to Pharmacists

The modern pharmacy profession is a pallid shade of its former glory. The responsibilities of the pharmacist has been largely subsumed by the doctor. It is doctors who now dole out drugs, pharmacists are now largely well educated pill counters and gatekeepers. The pharmacist is the last link on a long (and expensive) chain of events that separate drugs from the people who want to take them.

In the good old days before drug prohibition when an individual wanted drugs they consulted a pharmacist. The pharmacist was expected to be knowledgeable about the effects of the various drugs, knowing enough to recommend treatments for common ailments. Doctors were called to diagnose and treat more serious illnesses. Self-medication was an unstated assumption, and pharmacists played a key role in helping people make informed decisions.


The War on Drugs has Corrupted Medicine

By keeping certain drugs away from people who want to take them is a difficult task, one the police have had no lasting successes to date. But many drugs, especially opiates, are indispensable in medicine. For most people in the developed world there are only two sources for opiates, black market heroin, expensive and of dubious quality, or pharmaceutical opiates, pure and inexpensive (until they hit the black market where the value skyrockets). The appeal of getting one's drug supply legally, through a doctor, are obvious. So doctors must play two role, healer and detective. They must adequately treat pain while at the same time be on the lookout for malingerers (fakers). The fact that pain cannot be objectively measured, there is no scan or biochemical test to measure pain, only complicates things. The end result is that chronic pain is under-treated,     if treated at all. If an individual is label a "drug abuser" they often are ineligible for pain relief. Despite evidence that opiate addicts require higher dosages for effective analgesia, they are almost always given less. Apparently it is better to let an addict be in pain than to risk them feeling even a little good.

Drug addicts are the scapegoats of our modern age. Accordingly they are blamed for the fact that some chronic pain patients cannot get adequate treatment. Drug addicts however are among the most powerless members of society. They certainly do not have the power to keep drugs away from anybody. That power rests with doctors and government agencies like the FDA and DEA. Blaming addicts for the mistreatment of people in chronic pain may be popular, but it is incorrect.

People who use drugs see the acquisition and consumption of said drugs as a game. Not in the sense of a recreational game, but in the game theoretic sense of a series of goal-oriented, strategic interactions. For most opiate users their choices of supply are either an unreliable and price-inflated black market, or to see a doctor. Since doctor's are seldom accommodating when facing outright requests for narcotics, people employ subterfuge. Naturally doctors do not respond well to being lied to, and respond with hostility. An example of the venomous view of drug users was posted to a message board for medical students:

Yea, drug addicts are just filthy sub-humanoids who not only DO NOT deserve to be treated as a human being in help, but also DESERVE our undeniable rage and any afflictions that come across their path. I can't wait until the various anti-narcotic vaccinations make it out of clinical testing and into anyone who wants to go to public school.
Think about it like we are the Jews being persecuted by those Nazi-ass junkies.
I know that I am saying what everyone here is thinking, but are just too afraid to let their real opinions be known. Drug addiction is a disease worse than Hepatitis(ironic how most junkies get that too!) and just as contagious. We, the vanguard of future healthcare, must take an extreme position in order to truly accomplish what we have all desired: a quick and painful death for drug addicts.
Hyperbolic statements about "Nazi-ass junkies" aside, the lack of humanity of this would-be doctor would be shocking if it were directed at any other group. It could just as easily be homosexuals who "DO NOT deserved to be treated as human beings in help...but also DESERVE our undeniable rage and any afflictions that come across their path" or calls anti-homosexual vaccinations for grade school children. I have written about the stigmatizing language before. What is interesting is that this person views themselves as the "vanguard of healthcare" who must take an extreme position to eradicate the "contagious disease" of drug addiction. This person apparently thinks doctors should be both healers and drug warriors, two roles that are inimical to each other.

The Arrogance of Doctors: The God Complex
Some doctor's are said to suffer from a "God Complex", in which they assume they know their patient's needs better than the patient themselves. Many doctors labor under the delusion that they alone know how to heal. Oftentimes this arrogance extends to the entire person, the doctor knows their body and mind better than the individual himself or herself! The notion that someone may be self-medicating with opiates is dismissed out of hand. Here is another post on the same online board for medical students:
We are not depriving people of the pain relief they "need," rather we are not giving them addictive narcotics when it is not appropriate for them and will cause further health decline.
You say "need" but you have no idea what you "need." That is why you see a physician. You do have an idea what you "want," which is very different than a medical indication. You "want" to get high. You "need" to be safe and get healthy.
Using opioids out of a medical context is illegal, and highly dangerous. Self medication for mental disease is also highly dangerous and should not be attempted by patients.
Therefore, as physicians, we are fully opposed to junkies like you doing this.
We all prescribe opioids for legitimate uses, none of which include treating "mental ailments," nor the desire to meet the "wants" of our patients.
From this we can examine three claims:
1. People have no idea what they need, only physicians can make that determination. (People only know what they want)
2. Using Opioids outside of a medical context is illegal and highly dangerous
2. Self-medication for mental disease is also highly dangerous and should not be attempted by patients

To refute claim 1 we must first ask what gives a physician their authority. Physicians are expected to have completed certain educational requirements signified by the awarding of a medical degree and a license to practice from the government. And yet education alone cannot account for this incredible power physicians have to determine other's pharmacological need. After all a professor of pharmacology, who may know more than most physicians about the pharmacology of drugs, is ineligible for determining their own needs. Many drug users have no formal education, and yet are very knowledgeable about the pharmacology of the drugs they use. It is the license to practice medicine alone which gives doctors the power to determine the pharmacological needs of others. The control over drugs by the government is called pharmacracy, and for opiates the control is totalitarian.

Claim 2 states that using opiates outside of a narrow medical context is illegal and highly dangerous. There can be no argument that it is illegal. It may merely be pointed out that this was not always the case, and for most of the history of this country this was not the case. Using opiates may be dangerous, people do die of accidental overdoses, but is it highly dangerous?

One method of comparing the dangerousness of drugs is by comparing their therapeutic indexes. The therapeutic index is a ratio of lethal dose to therapeutic dose, larger numbers indicate safer drugs. For example alcohol, with a therapeutic index of 10, requires about ten times the dose that causes drunkenness to be lethal. The above image is from an article in American Scientist. While heroin is listed as the most lethal, it should be noted that the stated value is for intravenous route of administration. Oral morphine is not listed, but is probably similar to codeine. I have been looking for specific therapeutic index of opioids but have found widely diverting values. However, there is the synthetic opioid Sufentanil which is similar to fentanyl. It is extremely potent, but more importantly has an extremely high therapeutic index of approximately 25,000. This puts it near the top of the safest drugs listed.

If users had a choice of multiple opiates and synthetic opioids to choose from, self-medication would be no more dangerous than alcohol and in all probability much safer if options like Sufentanil or yet undiscovered opioids were made available. With the right information and pharmaceutical quality drugs of known dosage, the chance of an accidental overdose could be largely mitigated.

Claim 3 is similar to previous claims, though specific to dealing with self-medication for mental illness. Is self-medication for a mental illness highly dangerous? Should it not be attempted by patients?

This claim is too broad to refute completely, for example what mental illness and medication are we talking about? If the mental illness is depression and the medication marijuana, its hard to see that as being highly dangerous. But we are talking about opiates here, not marijuana. I have addressed the risks of using opiates relative to other drugs above. I see no reason why using opiates to treat one's own depression or pain would be more dangerous than using them "recreationally".

As a society we have been indoctrinated to believe that self-medication is wrong. Self-medication is pathologized as drug "abuse", both a symptom of a mental illness and a crime. I however, view self-medication as a fundamental human right: an extension of the right to be sovereign over our own bodies and minds. Unless there is a compelling case that a specific regime of self-medication will cause harm to others it should not be criminalized.

Why would doctors react so vociferously against exercising the right to medicate oneself? Concern for the health of the individual cannot completely explain this reaction. As the above quotes demonstrate, these particular doctors are not acting from concern, else they would support measures to make self-medication safer (ie harm reduction). These quotes represent a sense of vitriol directed toward the individual (hence the use of the word "junkie"). Doctors' are threatened by people who take control of their own health. If people do not need a doctor to heal themselves, doctors are robbed of both income and control. By controlling the supply of therapeutic drugs through a prescription system, supported by a criminal prohibition against entrepreneurs offering illicit healing ("drug pushers"), doctors are able to monopolize the practice of medicine.

Fortunately not all these future doctors are as ignorant, as the following post reveals.

You clearly haven't had to live live with severe pain or you would have no qualms about using the word "need" in this case. NSAIDs do not work for severe pain. Cannabinoids, substance P antagonists and the various other classes of analgesics that I know of aren't available so people with various types of pain have very few options. I would take becoming physically dependant on a drug over living my life in pain any day. My grandmother is constantly in pain and all the doctors prescribe her are aspirin and difene. She says the difene works but the side effects (such as stomach aches) outweigh the benefits.
You're clearly just another ignorant, box thinking medical practioner who is only capable of parroting off the things memorised in medical school rather than actually thinking logically about matters. I'm not a junkie, I don't use any drugs, I don't even drink coffee. I'm a chemistry student but I'm thinking of going to medical school after this degree and becoming a doctor because the world needs more doctors who are capable of thinking outside the box rather than blindly conforming to the consensus which is clearly profoundly flawed. Every doctor I have met so far seems to be incapable of thinking pharmacologically, but rather they only think in terms of what is commonly prescribed for what.
Since doctors don't help them, patients are willing to take the risks and attempt to self medicate and they should have the right to do so. You ignorant doctors assume the patients don't have the mental capabilities to find solutions for their own problems, solutions that actually work for them, as opposed to "solutions" that doctors think should work for them because its what they learned in medical school. You obviously have a very limited understanding of opioids. Using opioids out of a medical context isn't really that dangerous. Without considering drug interactions (i.e. serotonin syndrome in patients on SSRIs, additive sedation of patients on anxiolytics etc.), the main danger is risk of overdose which is something any semi intelligent individual should be able to avoid. IMO anyone who uses opioids (whether prescribed or not) should keep some naloxone nearby in case of emergency.
You say prescribing them for mental ailments is not a legitimate purpose. This is exactly what I mean by box thinking and the sheep/herd mentality. It doesn't matter to you what works and doesn't work, all that matters to you is whether something is commonly accepted. In other words, whether the rest of the herd is in accord with it. Cannabinoids aren't a medically accepted analgesic but that doesn't change the fact that they are safer and more effective than any of the analgesics commonly prescribed today. When I fractured my scaphoid, they had to operate and put pins in to hold the bones in place. They prescribed me dilaudid (hydromorphone) and it did absolutely nothing for me. It may work as an analgesic for others but it had absolutely no effect on me so I stopped taking it. I was in constant pain then a friend offered me some cannabis so I accepted his offer. The pain completely abated. This is an example of different people having different neurophysiology and consequently, benefitting from different substances. Opioids might work as analgesics for most people but not all people. Similarly SSRIs might work as antidepressants for some people but not all people.
More doctors like this fellow please.

Sunday, April 14, 2013

The Flower


This video is about legalizing marijuana, but couldn't it just as easily be about the poppy? Kudos to the creator.